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Article

PTEN: an emerging target in rheumatoid arthritis?

26 Apr 2024

Abstract excerpt

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical tumor suppressor protein that regulates various biological processes such as cell proliferation, apoptosis, and inflammatory responses by controlling the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PI3K/AKT) signaling pathway. PTEN plays a crucial role in the pathogenesis of rheumatoid arthritis (RA). Loss of PTEN may...

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PMID: 38671436
DOI: 10.1186/s12964-024-01618-6

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