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Article

Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies.

Journal of cellular biochemistry - 1 Sept 2015

Xi Yongming, Chen Yan

Abstract excerpt

Being a tumor suppressor, PTEN functions as a dual-specificity protein and phospholipid phosphatase and regulates a variety of cellular processes and signal transduction pathways. Loss of PTEN function has been detected frequently in different forms of cancers, such as breast, prostate and lung cancer, gastric and colon cancer, skin cancer, as well as endometrial carcinoma. In this review, we provide a summary of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 25773992
DOI: 10.1002/jcb.25159

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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