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Article

Ubiquitination regulates PTEN nuclear import and tumor suppression.

Cell - 12 Jan 2007

Trotman Lloyd C, Wang Xinjiang, Alimonti Andrea, Chen Zhenbang, Teruya-Feldstein Julie, Yang Haijuan, Pavletich Nikola P, Carver Brett S, Cordon-Cardo Carlos, Erdjument-Bromage Hediye, Tempst Paul, Chi Sung-Gil, Kim Hyo-Jong, Misteli Tom, Jiang Xuejun, Pandolfi Pier Paolo

Abstract excerpt

The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as a plasma-membrane lipid-phosphatase antagonizing the phosphoinositide 3-kinase/AKT cell survival pathway. However, PTEN is also found in cell nuclei, but mechanism, function, and relevance of nuclear localization remain unclear. We show that...

Topics

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Active Transport, Cell Nucleus
Endosomal Sorting Complexes Required for Transport
Glutamine
Hamartoma Syndrome, Multiple

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nedd4 Ubiquitin Protein Ligases

PTEN Phosphohydrolase

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Identifiers

PMID: 17218261
DOI: 10.1016/j.cell.2006.11.040
PMCID: PMC1855245

Genes

PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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