Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of PP2A A subunits in tumor suppression.

Cell adhesion & migration - 1 Jan 2000

Sablina Anna A, Hahn William C

Abstract excerpt

The protein phosphatase 2A (PP2A) family of heterotrimeric serine-threonine phosphatases participates in human cell transformation. Each functional PP2A complex contains one structural A subunit (A alpha or A beta), and mutations of both are found to occur at low frequency in human tumors. We have shown that A alpha functions as haploinsufficient tumor suppressor gene by regulating in part phosphatidylinositol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Protein Phosphatase 2

Share to Signal Transduction

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19262135
DOI: 10.4161/cam.1.3.4986
PMCID: PMC2634016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of PP2A A subunits in tumor suppression.PMID 19262135Read ↗

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.Semantic proximity Read ↗

B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity.Semantic proximity Read ↗

Functional importance of PP2A regulatory subunit loss in breast cancer.Semantic proximity Read ↗

Protein Phosphatase 2A in the Regulation of Wnt Signaling, Stem Cells, and CancerSemantic proximity Read ↗

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene.Semantic proximity Read ↗

Recurrent <i>PPP2R1A</i> Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell GrowthSemantic proximity Read ↗

The tumor suppressor PP2A Abeta regulates the RalA GTPase.Semantic proximity Read ↗

The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformationSemantic proximity Read ↗

Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy TargetSemantic proximity Read ↗

Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms.Semantic proximity Read ↗

RAS and PP2A activities converge on epigenetic gene regulationSemantic proximity Read ↗

Suppression of PP2A-B56α drives EMT in EGFR mutant non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.