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Article

Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia.

American journal of human genetics - 1 Apr 2009

Shi Hong, Tan Si-jie, Zhong Hua, Hu Wenwei, Levine Arnold, Xiao Chun-jie, Peng Yi, Qi Xue-bin, Shou Wei-hua, Ma Run-lin Z, Li Yi, Su Bing, Lu Xin

Abstract excerpt

The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in a cohort of 4029 individuals across Eastern Asia that suggests causative selection. Moreover, the two polymorphisms are not coselected....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19344876
DOI: 10.1016/j.ajhg.2009.03.009
PMCID: PMC2667983

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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