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Article

Natural selection and functional genetic variation in the p53 pathway.

Human molecular genetics - 15 Apr 2011

Sucheston Lara, Witonsky David B, Hastings Darcie, Yildiz Ozlem, Clark Vanessa J, Di Rienzo Anna, Onel Kenan

Abstract excerpt

The allele frequencies of two functional single-nucleotide polymorphisms (SNPs) in the p53 pathway, the MDM2 SNP309 and TP53 Arg72Pro, vary dramatically among populations. That the frequencies of the TP53 SNP follow a clinal distribution may suggest that selective pressure from environmental variables correlated with latitude contributed to these observed population differences. Recently, winter temperature and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21266458
DOI: 10.1093/hmg/ddr028
PMCID: PMC3063984

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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