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Article

TP53 codon 72 polymorphism in pigmentary phenotypes.

Journal of biosciences - 1 Mar 2012

Costa Karita Antunes, Guillo Lidia Andreu

Abstract excerpt

The p53 protein exerts different cellular functions, and recent findings have demonstrated its influence on the cascade of skin pigmentation during UV exposure. Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms. Therefore, this study aimed to determine...

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PMID: 22357201
DOI: 10.1007/s12038-012-9183-9

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