Article
The Role of TP53 in Adaptation and Evolution.
Cells - 3 Feb 2023
Voskarides Konstantinos, Giannopoulou Nefeli
Abstract excerpt
The TP53 gene is a major player in cancer formation, and it is considered the most important tumor suppressor gene. The p53 protein acts as a transcription factor, and it is involved in DNA repair, senescence, cell-cycle control, autophagy, and apoptosis. Beyond cancer, there is evidence that TP53 is associated with fertility, aging, and longevity. Additionally, more evidence exists that genetic variants in TP53...
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