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Article

Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.

PloS one - 1 Jan 2015

Jacovas Vanessa Cristina, Rovaris Diego Luiz, Peréz Orlando, de Azevedo Soledad, Macedo Gabriel Souza, Sandoval José Raul, Salazar-Granara Alberto, Villena Mercedes, Dugoujon Jean-Michel, Bisso-Machado Rafael, Petzl-Erler Maria Luiza, Salzano Francisco Mauro, Ashton-Prolla Patricia, Ramallo Virginia, Bortolini Maria Cátira

Abstract excerpt

The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantani, Anapia, Uros, Guarani Ñandeva, and Guarani Kaiowá populations, characterized as Native American or as having a...

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Share to Polymorphism, Single Nucleotide
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Source

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Identifiers

PMID: 26382048
DOI: 10.1371/journal.pone.0137823
PMCID: PMC4575214

Genes

LIF
MDM2
USP7
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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