The role of the small GTPase Rap in Drosophila R7 photoreceptor specification.

doi:10.1073/pnas.1115108109

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Article

The role of the small GTPase Rap in Drosophila R7 photoreceptor specification.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2012

Mavromatakis Yannis Emmanuel, Tomlinson Andrew

Abstract excerpt

The Drosophila R7 photoreceptor provides an excellent model system with which to study how cells receive and "decode" signals that specify cell fate. R7 is specified by the combined actions of the receptor tyrosine kinase (RTK) and Notch (N) signaling pathways. These pathways interact in a complex manner that includes antagonistic effects on photoreceptor specification: RTK promotes the photoreceptor fate,...

Topics

Alleles
Animals
Cdh1 Proteins
Cell Cycle Proteins
Cell Lineage
Crosses, Genetic
Drosophila Proteins
Drosophila melanogaster
Epistasis, Genetic
Genomics
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monomeric GTP-Binding Proteins

Photoreceptor Cells, Invertebrate

Receptors, Notch

Recombination, Genetic

Signal Transduction

Transcription Factors

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22355117
DOI: 10.1073/pnas.1115108109
PMCID: PMC3309734

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