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Article

Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2009

Gromley Adam, Churchman Michelle L, Zindy Frederique, Sherr Charles J

Abstract excerpt

The Arf tumor suppressor is expressed transiently during mouse male germ cell and eye development. Its inactivation compromises spermatogenesis as mice age and leads to aberrant postnatal proliferation of cells in the vitreous of the eye, resulting in blindness. In the testis, expression of p19(Arf) is limited to spermatogonia but is extinguished completely in spermatocytes, suggesting that Arf plays a...

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Identifiers

PMID: 19339492
DOI: 10.1073/pnas.0902310106
PMCID: PMC2664155

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