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Article

The Arf tumor suppressor regulates platelet-derived growth factor receptor beta signaling: a new view through the eyes of Arf(-/-) mice.

Cell cycle (Georgetown, Tex.) - 1 Oct 2005

Thornton J Derek, Silva Ricardo L A, Martin Amy C, Skapek Stephen X

Abstract excerpt

Arf is a key mammalian tumor suppressor gene known to be activated in response to aberrant mitogenic signals leading to both p53-dependent and -independent effects. We recently uncovered a new and somewhat unexpected function for mouse Arf as a regulator of mural cell accumulation within an ocular vascular bed destined to regress in the postnatal period. We found that the Arf gene product, p19(Arf), blocks mural...

Topics

Animals
Cyclin-Dependent Kinase Inhibitor p16
Eye
Genotype
Humans
Mice
Mice, Knockout
Receptor, Platelet-Derived Growth Factor beta
Signal Transduction
Tumor Suppressor Protein p14ARF

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16205116
DOI: 10.4161/cc.4.10.2109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16205116-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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