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Article

A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye.

Developmental biology - 1 Aug 2013

Zheng Yanbin, Devitt Caitlin, Liu Jing, Mei Jie, Skapek Stephen X

Abstract excerpt

The Arf tumor suppressor represents one of several genes encoded at the Cdkn2a and Cdkn2b loci in the mouse. Beyond its role blunting the growth of incipient cancer cells, the Arf gene also plays an essential role in development: its gene product, p19(Arf), is induced by Tgfβ2 in the developing eye to dampen proliferative signals from Pdgfrβ, which effect ultimately fosters the vascular remodeling required for...

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Source

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Identifiers

PMID: 23665474
DOI: 10.1016/j.ydbio.2013.05.003
PMCID: PMC4336776

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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