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Production of transgenic mice by random recombination of targeted genes in female germline stem cells

10 Dec 2010

Abstract excerpt

Oocyte production in most mammalian species is believed to cease before birth. However, this idea has been challenged with the finding that postnatal mouse ovaries possess mitotically active germ cells. A recent study showed that female germline stem cells (FGSCs) from adult mice were isolated, cultured long term and produced oocytes and progeny after transplantation into infertile mice. Here, we demonstrate the...

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PMID: 21149239
DOI: 10.1093/jmcb/mjq043

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