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Article

miR-34a is essential for p19<sup>Arf</sup>-driven cell cycle arrest

8 Jan 2014

Abstract excerpt

The Arf tumor suppressor gene product, p19(Arf), regulates cell proliferation in incipient cancer cells and during embryo development. Beyond its commonly accepted p53-dependent actions, p19(Arf) also acts independently of p53 in both contexts. One such p53-independent effect with in vivo relevance includes its repression of Pdgfrβ, a process that is essential for vision in the mouse. We have utilized cell...

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PMID: 24401748
DOI: 10.4161/cc.27725

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