Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.

doi:10.1073/pnas.1707292114

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Article

Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017

van Oosterwijk Jolieke G, Li Chunliang, Yang Xue, Opferman Joseph T, Sherr Charles J

Abstract excerpt

The mouse p19Arf (human p14ARF) tumor suppressor protein, encoded in part from an alternative reading frame of the Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53. Arf is not expressed in most normal tissues of young mice but is induced by high thresholds of aberrant hy...

Topics

3T3 Cells
Animals
Blindness
Cell Proliferation
Codon
Cyclin-Dependent Kinase Inhibitor p16
Deoxyribonucleases
Female
Fibroblasts
Fusion Proteins, bcr-abl
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ Cells

Male

Mice

Mice, Inbred C57BL

Mitochondria

Phenotype

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 28652370
DOI: 10.1073/pnas.1707292114
PMCID: PMC5514764

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-28652370-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.PMID 28652370Read ↗

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