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Article

Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017

van Oosterwijk Jolieke G, Li Chunliang, Yang Xue, Opferman Joseph T, Sherr Charles J

Abstract excerpt

The mouse p19Arf (human p14ARF) tumor suppressor protein, encoded in part from an alternative reading frame of the Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53. Arf is not expressed in most normal tissues of young mice but is induced by high thresholds of aberrant hyperproliferative signals, thereby activating p53 in incipient tumor cells that have experienced oncogene activation....

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PMID: 28652370
DOI: 10.1073/pnas.1707292114
PMCID: PMC5514764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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