Article
Male infertility caused by epididymal dysfunction in transgenic mice expressing a dominant negative mutation of retinoic acid receptor alpha 1.
Biology of reproduction - 1 Apr 1997
Costa S L, Boekelheide K, Vanderhyden B C, Seth R, McBurney M W
Abstract excerpt
Retinoids are thought to be required for the normal development and maturation of a number of tissues, including most epithelia. The action of retinoids appears to be mediated through the binding to retinoic acid receptors (RARs) in the nucleus. The activity of retinoic acid can be inhibited in c...
Topics
- Animals
- Epididymis
- Female
- Genes, Dominant
- Genes, myc
- Humans
- Immunohistochemistry
- Infertility, Male
- Keratins
- Litter Size
- Male
- Mammary Tumor Virus, Mouse
- Metaplasia
- Mice
- Mice, Inbred C3H
- Mice, Transgenic
- Mutation
- Promoter Regions, Genetic