Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

Cancer research - 15 Nov 1991

Puisieux A, Lim S, Groopman J, Ozturk M

Abstract excerpt

In lung and liver cancers, p53 mutations are mostly G:C to T:A transversions. This type of mutation is known to be induced by benzo(a)pyrene and aflatoxin B1 which are associated with the etiology of lung and liver cancers, respectively. Using a novel assay based on DNA polymerase fingerprint analysis, we identified p53 nucleotides targeted by these carcinogens. Thirteen of 14 nucleotide residues of the p53 gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Benzo(a)pyrene
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Fingerprinting

Share to Genes, p53

Share to Molecular Sequence Data

Share to Mutation

Share to Neoplasms

Source

Identifiers

PMID: 1933877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.PMID 1933877Read ↗

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.Semantic proximity Read ↗

p53 as a sensor of carcinogenic exposures: mechanisms of p53 protein induction and lessons from p53 gene mutations.Semantic proximity Read ↗

Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens.Semantic proximity Read ↗

TP53 tumor suppressor gene: a model for investigating human mutagenesis.Semantic proximity Read ↗

TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer.Semantic proximity Read ↗

p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer.Semantic proximity Read ↗

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.Semantic proximity Read ↗

p53 mutations in human cancers.Semantic proximity Read ↗

Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment.Semantic proximity Read ↗

p53 mutations in nonmalignant human liver: fingerprints of aflatoxins?Semantic proximity Read ↗

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons.Semantic proximity Read ↗

Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.