Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

Article

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

Cancer research - 15 Nov 1991

Puisieux A, Lim S, Groopman J, Ozturk M

Abstract excerpt

In lung and liver cancers, p53 mutations are mostly G:C to T:A transversions. This type of mutation is known to be induced by benzo(a)pyrene and aflatoxin B1 which are associated with the etiology of lung and liver cancers, respectively. Using a novel assay based on DNA polymerase fingerprint ana...

Topics

Aflatoxin B1
Base Sequence
Benzo(a)pyrene
DNA
DNA Fingerprinting
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.