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Article

Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes.

Molecular carcinogenesis - 1 May 1995

Cherpillod P, Amstad P A

Abstract excerpt

Human tobacco-related cancers show a high frequency of G-to-T transversions in several mutation hot-spot regions of the p53 tumor suppressor gene, probably the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene. To gain insight into the mechanism of formation of these G-to-...

Topics

Base Composition
Base Sequence
Benzo(a)pyrene
Biotransformation
Carcinoma, Hepatocellular
Codon
Evaluation Studies as Topic
Genes, p53
Genotype
Humans
Immunoblotting
Liver
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Site-Directed

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Tumor Cells, Cultured

Source

Identifiers

PMID: 7766306
DOI: 10.1002/mc.2940130104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7766306-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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