Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes.

Molecular carcinogenesis - 1 May 1995

Cherpillod P, Amstad P A

Abstract excerpt

Human tobacco-related cancers show a high frequency of G-to-T transversions in several mutation hot-spot regions of the p53 tumor suppressor gene, probably the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene. To gain insight into the mechanism of formation of these G-to-T transversions in tobacco-associated carcinogenesis, we studied the mutagenesis of p53 codons 247-250 by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Genes, p53
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 7766306
DOI: 10.1002/mc.2940130104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes.PMID 7766306Read ↗

The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts.Semantic proximity Read ↗

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.Semantic proximity Read ↗

Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China.Semantic proximity Read ↗

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers.Semantic proximity Read ↗

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.Semantic proximity Read ↗

Mutational hotspot in the p53 gene in human hepatocellular carcinomas.Semantic proximity Read ↗

Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.Semantic proximity Read ↗

Ultraviolet B light-induced mutagenesis of p53 hotspot codons 248 and 249 in human skin fibroblasts.Semantic proximity Read ↗

Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure?Semantic proximity Read ↗

p53 mutations in human cancers.Semantic proximity Read ↗

Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain.Semantic proximity Read ↗

Mutagenic potential of benzo[a]pyrene-derived DNA adducts positioned in codon 273 of the human P53 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.