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Article

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

Science (New York, N.Y.) - 18 Oct 1996

Denissenko M F, Pao A, Tang M, Pfeifer G P

Abstract excerpt

Cigarette smoke carcinogens such as benzo[a]pyrene are implicated in the development of lung cancer. The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution. Strong and selective adduct formation occurred at guanine positions in codons 157, 248, and 273. These same positions are the...

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Identifiers

PMID: 8832894
DOI: 10.1126/science.274.5286.430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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