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Article

Insoluble, speckled cytosolic distribution of retinoic acid receptor alpha protein as a marker of hepatic stellate cell activation in vitro.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Jul 2009

Mezaki Yoshihiro, Yamaguchi Noriko, Yoshikawa Kiwamu, Miura Mitsutaka, Imai Katsuyuki, Itoh Hideaki, Senoo Haruki

Abstract excerpt

Hepatic stellate cells (HSCs) are the major site of retinoid storage, and their activation is a key process in liver fibrogenesis. We have previously shown that expression of the retinoic acid receptor alpha (RARalpha) is upregulated in activated rat HSCs at a posttranscriptional level and that these RARalpha proteins showed a speckled distribution in the cytosol, despite their possession of a nuclear...

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Identifiers

PMID: 19332432
DOI: 10.1369/jhc.2009.953208
PMCID: PMC2699324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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