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Article

Activity and expression of ecto-5'-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line.

Life sciences - 2 Jan 2008

Andrade Cláudia M B, Roesch Gislaine C, Wink Márcia R, Guimarães Eduardo L M, Souza Luiz F, Jardim Fernanda Rafaela, Guaragna Regina M, Bernard Elena A, Margis Rogério, Borojevic Radovan, Battastini Ana Maria O, Guma Fátima C R

Abstract excerpt

Hepatic stellate cells (HSC) play a crucial role in the development of liver fibrosis and are important targets in liver disease therapy. Adenosine acts as an extracellular signaling molecule in various tissues and in liver this nucleoside exerts protective effects. Ecto-5'-nucleotidase/CD73 is a marker for the plasma membrane and is considered to be a key enzyme in the generation of adenosine in the...

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Identifiers

PMID: 18037449
DOI: 10.1016/j.lfs.2007.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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