Article
Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest.
Experimental cell research - 15 May 2006
de Léséleuc Louis, Denis François
Abstract excerpt
The orphan nuclear receptor Nur77 has been implicated in both growth and apoptosis, and its function and activity can be modulated by cellular redistribution. Green fluorescent protein-tagged Nur77 was used to evaluate the role of Nur77 intracellular redistribution in response to genotoxic stress. Selected DNA damaging agents and transcription inhibition lead to rapid redistribution of Nur77 into nuclear...
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