Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells.

The Journal of biological chemistry - 19 Mar 2004

Hazra Saswati, Xiong Shigang, Wang Jiaohong, Rippe Richard A, Krishna V, Chatterjee K, Tsukamoto Hidekazu

Abstract excerpt

Depletion of peroxisome proliferator-activated receptor gamma (PPARgamma) accompanies myofibroblastic transdifferentiation of hepatic stellate cells (HSC), the primary cellular event underlying liver fibrogenesis. The treatment of activated HSC in vitro or in vivo with synthetic PPARgamma ligands suppresses the fibrogenic activity of HSC. However, it is uncertain whether PPARgamma is indeed a molecular target of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Diterpenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Rats, Wistar

Share to Receptors, Cytoplasmic and Nuclear

Share to Transcription Factor AP-1

Share to Vitamin A

Source

Identifiers

PMID: 14702344
DOI: 10.1074/jbc.M310284200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells.PMID 14702344Read ↗

Adipogenic transcriptional regulation of hepatic stellate cells.Semantic proximity Read ↗

Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis.Semantic proximity Read ↗

Adipogenic phenotype of hepatic stellate cells.Semantic proximity Read ↗

Albumin mediates PPAR-gamma or C/EBP-alpha-induced phenotypic changes in pancreatic stellate cells.Semantic proximity Read ↗

Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation.Semantic proximity Read ↗

Epigenetic cell fate regulation of hepatic stellate cellsSemantic proximity Read ↗

Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis ResolutionSemantic proximity Read ↗

PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis.Semantic proximity Read ↗

PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.Semantic proximity Read ↗

Involvement of AP-1 proteins in pancreatic stellate cell activation in vitro.Semantic proximity Read ↗

Hepatic stellate cell line modulates lipogenic transcription factors.Semantic proximity Read ↗

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.