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Article

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.

The Journal of biological chemistry - 19 Nov 2004

Squires E James, Sueyoshi Tatsuya, Negishi Masahiko

Abstract excerpt

The pregnane X receptor (PXR) plays an important role in the response to xenobiotics and endogenous toxins. We have used a specific anti-PXR antibody in the Western blotting of mouse liver nuclear extracts to show that PXR is accumulated in the nucleus after treatment with 5-pregnen-3beta-ol-20-one-16alpha-carbonitrile (PCN), followed by an increase in Cyp3a11 mRNA. Expression of wild type PXR and various mutants...

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Identifiers

PMID: 15347657
DOI: 10.1074/jbc.M407281200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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