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Article

Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids.

Hepatology (Baltimore, Md.) - 1 Jan 2004

Hellemans Karine, Verbuyst Peggy, Quartier Erik, Schuit Frans, Rombouts Krista, Chandraratna Ross A S, Schuppan Detlef, Geerts Albert

Abstract excerpt

Activation of hepatic stellate cells (HSC) is a central event in the pathogenesis of liver fibrosis during chronic liver injury. We examined the expression of retinoic acid (RAR) and retinoid X receptors (RXR) during HSC activation and evaluated the influence of natural and synthetic retinoic acids (RA) on the phenotype of culture-activated HSC. The expression of the major RAR/RXR subtypes and isoforms was...

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PMID: 14752828
DOI: 10.1002/hep.20015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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