Article

Envelope-Limited Chromatin Sheets (ELCS) Formation in The Nuclear Envelope of HL-60/S4 Cells

2026-02-25

Abstract excerpt

Envelope-Limited Chromatin Sheets (ELCS) can be induced in human promyelocytic HL-60/S4 cells by treatment with retinoic acid (RA). After 4 days, the differentiated granulocytes exhibit multilobed nuclei with outgrowths of the nuclear envelope (NE) and associated heterochromatin extending into the surrounding cytoplasm (ELCS). These fascinating structures reveal a periodic meshwork of 30 nm chromatin fibers, when...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd14c19e-9838-50ea-b410-b2e6c3314e81
DOI: 10.64898/2026.02.23.707298

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Envelope-Limited Chromatin Sheets (ELCS) Formation in The Nuclear Envelope of HL-60/S4 CellsDOI 10.64898/2026.02.23.707298Read

Nucleosome repositioning during differentiation of a human myeloid leukemia cell lineSemantic proximity Read

Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells.Semantic proximity Read

The Effects of Lamin B Receptor knockdown on a Myeloid Leukemia CellSemantic proximity Read

Polarization Increases Nuclear Stiffness in Macrophages Despite Reduction in Lamin A/C LevelsSemantic proximity Read

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies.Semantic proximity Read

Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression.Semantic proximity Read

Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7.Semantic proximity Read

PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phaseSemantic proximity Read

Blurring the boundary: the nuclear envelope extends its reach.Semantic proximity Read

Chromatin histone modifications and rigidity affect nuclear morphology independent of laminsSemantic proximity Read

PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replicationSemantic proximity Read

The functional roles of PML nuclear bodies in genome maintenanceSemantic proximity Read