Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the AF-2 region abolish ligand-induced intranuclear immobilization of the liver X receptor alpha.

Experimental cell research - 15 Aug 2008

Prüfer Kirsten, Hernandez Christian, Gilbreath Matthew

Abstract excerpt

The liver X receptors (LXR) alpha and beta are ligand-induced transcription factors that regulate the expression of genes important for cholesterol metabolism, lipogenesis, and other metabolic pathways. Despite their high degree of similarity, LXRs have redundant as well as nonredundant functions. The regulation of LXRs' intranuclear mobility most likely plays a major role in the regulation of their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Ligands
Share to Liver X Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to Orphan Nuclear Receptors

Share to Protein Transport

Share to Receptors, Cytoplasmic and Nuclear

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 18599038
DOI: 10.1016/j.yexcr.2008.05.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the AF-2 region abolish ligand-induced intranuclear immobilization of the liver X receptor alpha.PMID 18599038Read ↗

Nuclear localization of liver X receptor alpha and beta is differentially regulated.Semantic proximity Read ↗

Liver X receptor beta with mutations in the activation function-2 region is excluded from the nucleolus.Semantic proximity Read ↗

The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions.Semantic proximity Read ↗

Auto-silencing by the retinoid X receptor.Semantic proximity Read ↗

In vivo monitoring of the recruitment and activation of AP-1 by Arf1.Semantic proximity Read ↗

Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.Semantic proximity Read ↗

Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci.Semantic proximity Read ↗

Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer PartnerSemantic proximity Read ↗

Impaired transitioning of the FXR ligand binding domain to an active state underlies an FXR-associated PFIC phenotypeSemantic proximity Read ↗

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.Semantic proximity Read ↗

Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function.Semantic proximity Read ↗

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.