Article
Retinol uptake and metabolism, and cellular retinol binding protein expression in an in vitro model of hepatic stellate cells.
Molecular and cellular biochemistry - 1 Oct 1998
Vicente C P, Fortuna V A, Margis R, Trugo L, Borojevic R
Abstract excerpt
Liver is a major site of retinoid metabolism and storage, and more than 80% of the liver retinoids are stored in hepatic stellate cells. These cells represent less than 1% of the total liver protein, reaching a very high relative intracellular retinoid concentration. The plasma level of retinol is maintained close to 2 microM, and hepatic stellate cells have to be able both to uptake or to release retinol...
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