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Article

Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma.

Intervirology - 1 Jan 2008

Bock C-Thomas, Toan Nguyen L, Koeberlein Bernd, Song Le H, Chin Ruth, Zentgraf Hanswalter, Kandolf Reinhard, Torresi Joseph

Abstract excerpt

OBJECTIVE: The hepatitis B virus X (HBx) protein plays an important role in the pathogenesis of hepatocellular carcinoma (HCC). One potential mechanism by which HBx can cause liver cancer may involve intracellular distribution and consecutively modulation of the proliferative important STAT/SOCS signaling with upregulation of STAT3. METHODS: 153 Vietnamese HBV-infected patients, including 48 patients with HCC,...

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Share to Gene Expression Regulation, Viral
Share to STAT Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Suppressor of Cytokine Signaling 1 Protein

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Source

Identifiers

PMID: 19321929
DOI: 10.1159/000209672

Genes

STAT3
SOCS1
SOCS3
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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