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Article

Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes

6 Jun 2019

Abstract excerpt

Hepatitis B virus X protein (HBx) is a promising drug target since it promotes the degradation of the host structural maintenance of chromosomes 5/6 complex (Smc5/6) that inhibits HBV transcription. To date, it has not been possible to study HBx in physiologically relevant cell culture systems due to the lack of a highly specific and selective HBx antibody. In this study, we developed a novel monoclonal HBx...

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PMID: 31167911
DOI: 10.1128/jvi.00248-19

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Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human HepatocytesPMID 31167911Read ↗

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after InfectionSemantic proximity Read ↗

Conserved yet Divergent Smc5/6 Complex Degradation by Mammalian Hepatitis B Virus X ProteinSemantic proximity Read ↗

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV ReplicationSemantic proximity Read ↗

HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNASemantic proximity Read ↗

Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals.Semantic proximity Read ↗

E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation.Semantic proximity Read ↗

Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive ReviewSemantic proximity Read ↗

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase ComplexSemantic proximity Read ↗

Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivoSemantic proximity Read ↗

Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation.Semantic proximity Read ↗

HBXIP, Cellular Target of Hepatitis B Virus Oncoprotein, Is a Regulator of Centrosome Dynamics and CytokinesisSemantic proximity Read ↗

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.Semantic proximity Read ↗

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