Article
UVDDB p127-binding modulates activities and intracellular distribution of hepatitis B virus X protein.
Oncogene - 7 Sept 2000
Sitterlin D, Bergametti F, Transy C
Abstract excerpt
Mammalian hepatitis B viruses encode a unique regulatory protein termed X, which is essential for infection and likely plays a role in the carcinogenic process associated with hepadnaviral infection. Among the numerous properties ascribed to X protein, two have been widely documented: promiscuous transcriptional transactivation and proapoptosis. However, full understanding of the mechanisms underlying these...
Topics
- Apoptosis
- Biological Transport
- Cell Line
- Cell Nucleus
- Cell Survival
- DNA-Binding Proteins
- Hepatitis B Virus, Woodchuck
- Humans
- Mutation
- Recombinant Proteins
- Trans-Activators