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Article

Subcellular localization and transcriptional repressor activity of HBx on p21(WAF1/Cip1) promoter is regulated by ERK-mediated phosphorylation.

Biochemical and biophysical research communications - 2 Jul 2004

Noh Eun Joo, Jung Hee-Jung, Jeong Gajin, Choi Kyeong Sook, Park Hyun Jin, Lee Chang-Hun, Lee Jong-Soo

Abstract excerpt

The protein encoded by the hepatitis B viral X-gene, HBx, is essential for viral infection and has been shown to regulate gene transcription and the Ras signaling pathway including Raf, MEK, and ERK. To better understand regulatory mechanism of HBx functions, we investigated whether ERK1/2-induced phosphorylation of HBx regulates its transcriptional activity on p21(WAF1/Cip1) promoter. HBx-genotype A (WT1) and...

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PMID: 15184045
DOI: 10.1016/j.bbrc.2004.05.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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