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Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesis

1 May 1996

Abstract excerpt

The hepatitis B virus (HBV) genome encodes a 154 amino acid protein termed X (HBx, hepatitis B x protein), which is a promiscuous transcriptional activator of polymerase II and III promoters. HBx upregulates a wide range of cellular and viral genes and is thought to facilitate viral pregenome and mRNA transcription; however, its precise role in the viral replication cycle remains to be elucidated. The functional...

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Identifiers

PMID: 8871869
DOI: 10.1111/j.1365-2893.1996.tb00001.x

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