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Article

Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function.

Free radical biology & medicine - 1 Oct 2013

Tang Wenbo, Bentley Amy R, Kritchevsky Stephen B, Harris Tamara B, Newman Anne B, Bauer Douglas C, Meibohm Bernd, Cassano Patricia A

Abstract excerpt

Antioxidant enzymes play an important role in the defense against oxidative stress in the lung and in the pathogenesis of chronic obstructive pulmonary disease (COPD). Sequence variation in genes encoding antioxidant enzymes may alter susceptibility to COPD by affecting longitudinal change in lung function in adults. We genotyped 384 sequence variants in 56 candidate genes in 1281 African American and 1794...

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Source

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Identifiers

PMID: 23688726
DOI: 10.1016/j.freeradbiomed.2013.05.016
PMCID: PMC4060265

Genes

GCLC
GLRX2
SOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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