Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes.

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Article

Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes.

The New biologist - 1 Sept 1991

Sawai S, Shimono A, Hanaoka K, Kondoh H

Abstract excerpt

The N-myc gene is considered to play a major regulatory role in embryogenesis of the mouse because of its high expression in the organogenesis period and its encoding of nuclear proteins with DNA binding motifs. To elucidate the putative regulatory function of N-myc in embryogenesis, we undertook to inactivate this gene in ES cells. The N-myc alleles were disrupted in ES cells, line E14, by means of homologous...

Topics

Alleles
Animals
Base Sequence
Blastocyst
Cell Line
Cinnamates
Drug Resistance
Embryonic and Fetal Development
Genes, Lethal
Genes, myc
Genetic Vectors
Hygromycin B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C3H

Mice, Inbred C57BL

Mice, Inbred ICR

Molecular Sequence Data

Neomycin

Source

Open in PubMed

Identifiers

PMID: 1931830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1931830-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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