Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

doi:10.1101/gad.6.12a.2248

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Article

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

Genes & development - 1 Dec 1992

Charron J, Malynn B A, Fisher P, Stewart V, Jeannotte L, Goff S P, Robertson E J, Alt F W

Abstract excerpt

The N-myc gene encodes a putative transcription factor that is thought to function in the regulation of gene expression during cell differentiation and/or growth. To examine the role of N-myc during development, we have used targeted mutagenesis in embryonic stem cells to produce a mouse line tha...

Topics

Alleles
Animals
Blotting, Southern
Brain
Cells, Cultured
Central Nervous System
Embryonic and Fetal Development
Female
Fetal Death
Genes, myc
Heart
Heterozygote
Homozygote
Kidney
Male
Mice
Mice, Inbred C57BL
Mutagenesis

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