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Article

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells.

Molecular and cellular biology - 1 Dec 1990

Stanton B R, Reid S W, Parada L F

Abstract excerpt

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N...

Topics

Alleles
Animals
Blotting, Northern
Blotting, Southern
Cell Line
Embryo, Mammalian
Genes, myc
Mice
Mutagenesis, Insertional
Poly A
RNA
RNA, Messenger
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

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Identifiers

PMID: 1701023
DOI: 10.1128/mcb.10.12.6755-6758.1990
PMCID: PMC362953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1701023-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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