Article
Inactivation of the murine N-ras gene by gene targeting.
Oncogene - 1 Dec 1992
Cases S, Dautry F
Abstract excerpt
The mammalian ras genes have been implicated in the genesis of a wide variety of tumors. Although it is likely that they play an essential role in signal transduction, their specific function is still unknown. To initiate a genetic analysis of the ras genes in mammals we inactivated the N-ras gene in murine embryonic stem cells by gene targeting. The frequency of integration at the N-ras locus of our targeting...
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