Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.

doi:10.1101/gad.6.12a.2235

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Article

Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.

Genes & development - 1 Dec 1992

Stanton B R, Perkins A S, Tessarollo L, Sassoon D A, Parada L F

Abstract excerpt

myc genes are thought to function in the processes of cellular proliferation and differentiation. To gain insight into the role of the N-myc gene during embryogenesis, we examined its expression in embryos during postimplantation development using RNA in situ hybridization. Tissue- and cell-specific patterns of expression unique to N-myc as compared with the related c-myc gene were observed. N-myc transcripts...

Topics

Alleles
Animals
Blotting, Southern
Embryonic and Fetal Development
Epithelium
Fetal Death
Gastric Mucosa
Gene Expression Regulation
Genes, myc
Genotype
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intestinal Mucosa

Intestines

Lung

Mice

Multigene Family

Mutagenesis, Site-Directed

Nervous System

Source

Open in PubMed

Identifiers

PMID: 1459449
DOI: 10.1101/gad.6.12a.2235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1459449-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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