Article
Mutation of N-myc in mice: what does the phenotype tell us?
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Apr 1993
Davis A, Bradley A
Abstract excerpt
Oncogenesis is manifested as uncontrolled cellular proliferation and in some situations a failure of normal differentiation in the transformed cell. This has led to speculation that the normal role of proto-oncogenes during development may be to mediate the relationship between proliferation and differentiation. The advent of gene targeting in ES cells allows the role oncogenes in development to be tested...
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