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Article

Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease

9 Jul 2021

Abstract excerpt

Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration. Its nonapoptotic functions, including regulation of cellular differentiation/maturation, innate immunity, mitochondrial homeostasis, and autophagy, reveal a multimodal landscape of caspase-9 functions in health and disease. Recent work has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34305609
DOI: 10.3389/fphar.2021.701301

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