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Article

Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2009

Shang Enyuan, Wang Xiangyuan, Wen Duancheng, Greenberg David A, Wolgemuth Debra J

Abstract excerpt

The BET subfamily of bromodomain-containing genes is characterized by the presence of two bromodomains and a unique ET domain at their carboxyl termini. Here, we show that the founding member of this subfamily, Brd2, is an essential gene by generating a mutant mouse line lacking Brd2 function. Homozygous Brd2 mutants are embryonic lethal, with most Brd2(-/-) embryos dying by embryonic day 11.5. Before death, the...

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Source

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Identifiers

PMID: 19301389
DOI: 10.1002/dvdy.21911
PMCID: PMC2771124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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