Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

Molecular and cellular biology - 1 Jun 2002

Houzelstein Denis, Bullock Simon L, Lynch Denise E, Grigorieva Elena F, Wilson Valerie A, Beddington Rosa S P

Abstract excerpt

In a gene trap screen we recovered a mouse mutant line in which an insertion generated a null allele of the Brd4 gene. Brd4 belongs to the Fsh/Brd family, a group of structurally related proteins characterized by the association of two bromodomains and one extraterminal domain. Members of this family include Brd2/Ring3/Fsrg1 in mammals, fs(1)h in Drosophila, and Bdf1 in Saccharomyces cerevisiae. Brd4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomes, Human, Pair 19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic and Fetal Development

Share to Gene Expression Regulation, Developmental

Share to Growth Disorders

Share to Homozygote

Share to Oncogene Proteins, Fusion

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 11997514
DOI: 10.1128/MCB.22.11.3794-3802.2002
PMCID: PMC133820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.PMID 11997514Read ↗

Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.Semantic proximity Read ↗

The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis.Semantic proximity Read ↗

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.Semantic proximity Read ↗

The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte–embryo transitionSemantic proximity Read ↗

Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth ArrestSemantic proximity Read ↗

BET Proteins Regulate Expression of Osr1 in Early Kidney DevelopmentSemantic proximity Read ↗

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.Semantic proximity Read ↗

Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.Semantic proximity Read ↗

Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene.Semantic proximity Read ↗

The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosusSemantic proximity Read ↗

Redd1 is a novel marker of testis development but is not required for normal male reproduction.Semantic proximity Read ↗

Implantation and Gastrulation Abnormalities Characterize Early Embryonic Lethal Mouse LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.