Article
Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells.
Biochemical and biophysical research communications - 7 Sept 2012
Tsume Mami, Kimura-Yoshida Chiharu, Mochida Kyoko, Shibukawa Yukinao, Amazaki Saori, Wada Yoshinao, Hiramatsu Ryuji, Shimokawa Kayo, Matsuo Isao
Abstract excerpt
To understand genetic programs controlling mammalian central nervous system (CNS) development, we have identified one transgene-inserted mutation, which showed embryonic lethality during neurulation. Determination of the transgene integration site and rescue experiments revealed that the Brd2 gene, whose products specifically bind acetylated histone H4 and can mediate transcription, was the cause of this...
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