Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemia

21 Oct 2003

Abstract excerpt

Transgenic mice with lymphoid-restricted overexpression of the double bromodomain protein bromodomain-containing 2 (Brd2) develop splenic B-cell lymphoma and, upon transplantation, B-cell leukemia with leukemic infiltrates in liver and lung. Brd2 is a nuclear-localized transcription factor kinase that is most closely related to TATA box binding protein-associated factor, 250 kDa (TAF(II)250) and the Drosophila...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral-associated cancers and disorders
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14563639
DOI: 10.1182/blood-2003-06-2116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemiaPMID 14563639Read ↗

Tumor-specific and Proliferation-specific Gene Expression Typifies Murine Transgenic B Cell LymphomagenesisSemantic proximity Read ↗

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsSemantic proximity Read ↗

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsSemantic proximity Read ↗

Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.Semantic proximity Read ↗

New murine models of aggressive lymphoma.Semantic proximity Read ↗

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Semantic proximity Read ↗

B-cell tumor development in Tet2-deficient mice.Semantic proximity Read ↗

TET2 loss promotes premalignant survival and clonal selection in MYC-driven B cell lymphomaSemantic proximity Read ↗

The human <i>BCL6</i> transgene promotes the development of lymphomas in the mouseSemantic proximity Read ↗

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.Semantic proximity Read ↗

Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.