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Article

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.

Molecular and cellular biology - 1 Aug 2004

Chiang Y Jeffrey, Kim Sahn-Ho, Tessarollo Lino, Campisi Judith, Hodes Richard J

Abstract excerpt

TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further observed that the embryonic lethality of TIN2 mutant mice was not affected by inactivation of the...

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Identifiers

PMID: 15254230
DOI: 10.1128/MCB.24.15.6631-6634.2004
PMCID: PMC444850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.PMID 15254230Read ↗

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TIN2, a new regulator of telomere length in human cellsSemantic proximity Read ↗

Role of the TRF2 Telomeric Protein in Cancer and AgingSemantic proximity Read ↗

Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1Semantic proximity Read ↗

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