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Article

The Conserved 12-Amino Acid Stretch in the Inter-Bromodomain Region of BET Family Proteins Functions as a Nuclear Localization Signal

1 Jan 2012

Abstract excerpt

The bromodomain and extraterminal (BET) family is a group of chromatin-binding proteins characterized by two bromodomains, an extraterminal (ET) domain, and several other conserved regions of unknown function. In humans, the BET family consists of four members, BRD2, BRD3, BRD4 and BRDT, that all normally localize to the nucleus. We identified a 12-amino acid stretch in the inter-bromodomain region that is...

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PMID: 22971749
DOI: 10.1248/bpb.b12-00527

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