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Article

Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies.

BioMed research international - 1 Jan 2023

Almaghrabi Sarah, Lovewell Thomas, Azzouz Mimoun, Tazi Ahnini Rachid

Abstract excerpt

Autoimmune polyglandular syndrome type 1 (APS-1) is an inherited autosomal disorder. The most common clinical features of the disease include adrenocortical failure, hypoparathyroidism (HP), and chronic mucocutaneous candidiasis (CMC). APS-1 is caused by mutations in the autoimmune regulator (AIRE) gene. AIRE is a transcriptional factor involved in the regulation of thousands of genes in the thymus. It...

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Identifiers

PMID: 36685668
DOI: 10.1155/2023/7960443
PMCID: PMC9848810

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