Article
The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.
PloS one - 1 Jan 2013
de la Puerta María Luisa, Trinidad Antonio G, Rodríguez María del Carmen, de Pereda José María, Sánchez Crespo Mariano, Bayón Yolanda, Alonso Andrés
Abstract excerpt
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus. This polymorphism changes an R by a W in the P1 Pro rich motif of LYP, which binds to CSK SH3 domain, another negative regulator of TCR signaling. Based on the analysis of the mouse...
Topics
- Autoimmune Diseases
- Autoimmunity
- CSK Tyrosine-Protein Kinase
- Electrophoresis, Polyacrylamide Gel
- Flow Cytometry
- HEK293 Cells
- Humans
- Immunohistochemistry
- Jurkat Cells
- Models, Molecular
- Phosphorylation
- Polymorphism, Single Nucleotide
- Protein Binding